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KMID : 1123920100240010080
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Korean Journal of Oriental Physiology and Pathology
2010 Volume.24 No. 1 p.80 ~ p.84
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Codonopsis Lanceolata Inhibits Inflammation through Regulation of MAPK in LPS-stimulated RAW264.7 cells
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Kim Bum-Hoi
Lee Yong-Tae
Kang Kyung-Hwa
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Abstract
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Codonopsis Lanceolata (CL) has been widely used in Oriental medicine for treatment of chronic inflammatory diseases, such as bronchitis, cough, and spasm; however, the mechanism of its anti-inflammatory activity has not been clarified. In this study, therefore, we investigated the inhibitory effect of CL on LPS-induced inflammation. The effect of CL was analyzed by ELISA, RT-PCR and Western blotting in LPS-stimulated RAW264.7 cells. We found that CL suppressed not only the mRNA expression of pre-inflammatory cytokines, inducible nitric oxide synthase (iNOS), and cyclooxygenase (COX)-2, but also the phosphorylation of ERK1/2, JNK1/2 and p38 MAPK. These results suggest that CL exerts an anti-inflammatory effect through the regulation of the mitogen-activated protein kinases (MAPK) pathway, thereby decreasing production of pre-inflammatory cytokines, NO, and PGE2.
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KEYWORD
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codonopsis anceolata (CL), inflammation, mitogen-activated protein kinases (MAPK), RAW264.7
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